The International Space Station and the Docked Space Shuttle Endeavour
This image of the International Space Station and the docked space shuttle Endeavour, flying at an altitude of approximately 220 miles, was taken by Expedition 27 crew member Paolo Nespoli from the Soyuz TMA-20 following its undocking on May 23, 2011 (USA time). It is the first-ever image of a space shuttle docked to the International Space Station.
(via NASA)
Using the Space Shuttle for scale, this shot really gives you an idea of how large the ISS has become. Click through for the high-res version.
(via magicrob)